SIGNATURES
Pursuant to the requirements of Section 13 or 15(d) of the Securities ExchangeAct of 1934, the
Registrant has duly caused this report on Form 10-K to be signed on its behalf by the undersigned, thereunto
duly authorized on the 27th day of February, 2015.
ISIS PHARMACEUTICALS, INC.
By:
/s/ STANLEYT. CROOKE
Stanley T. Crooke, M.D., Ph.D.
Chairman of the Board, President and Chief
Executive Officer (Principal executive officer)
POWEROFATTORNEY
KNOWALLMENBYTHESE PRESENTS, that each person whose signature appears below constitutes
and appoints Stanley T. Crooke and Elizabeth L. Hougen, or any of them, his or her attorney-in-fact, each
with the power of substitution, for him or her in any and all capacities, to sign any amendments to this
Report, and to file the same, with exhibits thereto and other documents in connection therewith, with the
Securities and Exchange Commission, hereby ratifying and confirming all that each of said attorneys-in-fact,
or his or her substitute or substitutes, may do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities ExchangeAct of 1934, this report has been signed below
by the following persons on behalf of the Registrant and in the capacities and on the dates indicated.
Signatures
Title
Date
/s/ STANLEYT. CROOKE
Chairman of the Board, President, and
Chief Executive Officer (Principal executive
officer)
February 27, 2015
Stanley T. Crooke, M.D., Ph.D.
/s/ B. LYNNE PARSHALL
Director, Chief Operating Officer and
Secretary
February 27, 2015
B. Lynne Parshall, J.D.
/s/ ELIZABETHL. HOUGEN Senior Vice President, Finance and
Chief Financial Officer (Principal financial
and accounting officer)
February 27, 2015
Elizabeth L. Hougen
/s/ SPENCERR. BERTHELSEN Director
February 27, 2015
Spencer R. Berthelsen, M.D.
/s/ BREAUXCASTLEMAN Director
February 27, 2015
Breaux Castleman
/s/ JOSEPHKLEIN
Director
February 27, 2015
Joseph Klein, III.
/s/ JOSEPHLOSCALZO
Director
February 27, 2015
Joseph Loscalzo, M.D., Ph.D.
/s/ FREDERICKT. MUTO Director
February 27, 2015
Frederick T. Muto, Esq.
/s/ JOSEPHH. WENDER
Director
February 27, 2015
Joseph H. Wender
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