ISIS PHARMACEUTICALS, INC.
INDEXTOCONSOLIDATEDFINANCIALSTATEMENTS
Page
Report of Independent Registered PublicAccounting Firm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . F-2
Consolidated Balance Sheets at December 31, 2014 and 2013 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . F-3
Consolidated Statements of Operations for the years ended December 31, 2014, 2013 and 2012 . . . . . . . . . . F-4
Consolidated Statements of Comprehensive Loss for the years ended December 31, 2014, 2013 and 2012 . . F-5
Consolidated Statements of Stockholders’ Equity for the years ended December 31, 2014, 2013 and 2012 . . F-6
Consolidated Statements of Cash Flows for the years ended December 31, 2014, 2013 and 2012. . . . . . . . . . F-7
Notes to Consolidated Financial Statements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . F-8
F-1