UNITED STATES
SECURITIESANDEXCHANGECOMMISSION
Washington, DC 20549
FORM10-K
ANNUALREPORTPURSUANTTOSECTION 13 OR 15(d) OF
THE SECURITIES EXCHANGEACTOF 1934
For the fiscal year ended December 31, 2014
Commission file number 0-19125
Isis Pharmaceuticals, Inc.
(Exact name of Registrant as specified in its charter)
Delaware
33-0336973
(State or other jurisdiction of
incorporation or organization)
(IRS Employer Identification No.)
2855 Gazelle Court, Carlsbad, CA92010
(Address of principal executive offices, including zip code)
760-931-9200
(Registrant’s telephone number, including area code)
Securities registered pursuant to Section 12(b) of theAct:
None
Securities registered pursuant to Section 12(g) of theAct:
Common Stock, $.001 Par Value
Indicate by check mark whether the Registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.
Yes
☒
No
□
Indicate by check mark whether the Registrant is not required to file reports pursuant to Section 13 or Section 15(d) of theAct.
Yes
□
No
☒
Indicate by check mark whether the Registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities
ExchangeAct of 1934 during the preceding 12 months (or for such shorter period that the Registrant was required to file such reports),
and (2) has been subject to such filing requirements for the past 90 days. Yes
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No
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Indicate by check mark whether the registrant has submitted electronically and posted on its corporateWeb site, if any, every
Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the
preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). Yes
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No
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Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will
not be contained, to the best of Registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part III
of this Form 10-K or any amendment to this Form 10-K.
□
Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller
reporting company. See definition of ‘‘large accelerated filer,’’ ‘‘accelerated filer’’ and ‘‘smaller reporting company’’ in Rule 12b-2 of the
ExchangeAct. (Check one):
Large accelerated filer
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Accelerated filer
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Non-accelerated filer
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(Do not check if a smaller reporting company)
Smaller reporting company
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Indicate by check mark whether the Registrant is a shell company (as defined in Rule 12b-2 of theAct). Yes
□
No
☒
The approximate aggregate market value of the voting common stock held by non-affiliates of the Registrant, based upon the last
sale price of the common stock reported on The NASDAQGlobal Select Market was $3,377,077,105 as of June 30, 2014.*
The number of shares of voting common stock outstanding as of February 23, 2015 was 119,018,331.
DOCUMENTS INCORPORATEDBYREFERENCE
The Exhibit Index (ItemNo. 15) located on pages 126 to 133 incorporates several documents by reference as indicated therein.
* Excludes 19,641,255 shares of common stock held by directors and officers and by stockholders whose beneficial ownership is known by the Registrant to
exceed 10%of the common stock outstanding at June 30, 2014. Exclusion of shares held by any person should not be construed to indicate that such person
possesses the power, direct or indirect, to direct or cause the direction of the management or policies of the Registrant, or that such person is controlled by or
under common control with the Registrant.
