Isis Pharmaceuticals, Inc. Form 10K - page 89

As of the end of the period covered by this report on Form 10-K, we carried out an evaluation of our
disclosure controls and procedures under the supervision of, and with the participation of our management,
including our Chief Executive Officer and Chief Financial Officer. Based on our evaluation, our Chief Executive
Officer and Chief Financial Officer concluded that our disclosure controls and procedures were effective as of
December 31, 2014.
Management’s Report on Internal Control over Financial Reporting
Our management is responsible for establishing and maintaining adequate internal control over financial
reporting, as defined in ExchangeAct Rules 13a-15(f). Our internal control over financial reporting is a process
designed under the supervision of our Chief Executive Officer and Chief Financial Officer to provide reasonable
assurance regarding the reliability of financial reporting and the preparation of our financial statements for
external purposes in accordance with United States generally accepted accounting principles.
As of December 31, 2014, we assessed the effectiveness of our internal control over financial reporting
based on the criteria for effective internal control over financial reporting under the 2013 ‘‘Internal
Control—Integrated Framework,’’ issued by the Committee of Sponsoring Organizations, or COSO, of the
Treadway Commission, under the supervision of, and with the participation of our management, including our
Chief Executive Officer and Chief Financial Officer. Based on that assessment, our management concluded that
we maintained effective internal control over financial reporting as of December 31, 2014.
Ernst &Young LLP, an independent registered public accounting firm, audited the effectiveness of our
internal control over financial reporting as of December 31, 2014, as stated in their attestation report, which is
included elsewhere herein.
Changes in Internal Control over Financial Reporting
The above assessment did not identify any change in our internal control over financial reporting that
occurred during our latest fiscal quarter and that has materially affected, or is reasonably likely to materially
affect, our internal control over financial reporting.
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