Joseph Loscalzo,
age 63, is Hersey Professor of the Theory and Practice of Medicine at HarvardMedical
School, Chairman of the Department of Medicine, and Physician-in-Chief at Brigham andWomen’s Hospital. Dr.
Loscalzo received his A.B. degree, summa cum laude, his Ph.D. in biochemistry, and his M.D. from the
University of Pennsylvania. His clinical training was completed at Brigham andWomen’s Hospital and Harvard
Medical School, where he served as Resident and Chief Resident in medicine and Fellow in cardiovascular
medicine. Post-training, Dr. Loscalzo joined the Harvard faculty and staff at Brigham andWomen’s Hospital in
1984. He rose to the rank of Associate Professor of Medicine, Chief of Cardiology at theWest Roxbury Veterans
AdministrationMedical Center, and Director of the Center for Research in Thrombolysis at Brigham and
Women’s Hospital. He joined the faculty of Boston University in 1994, first as Chief of Cardiology and, in 1997,
Wade Professor and Chair of Medicine, Professor of Biochemistry, and Director of theWhitaker Cardiovascular
Institute. He returned to Harvard and Brigham andWomen’s Hospital in 2005.
The Board believes Dr. Loscalzo is uniquely suited to serve on the Board primarily because of his extensive
scientific expertise, including 25 years of research in the areas of vascular biology, thrombosis, and
atherosclerosis, and practical knowledge as a practicing physician. Dr. Loscalzo’s expertise and role as a leading
cardiologist is particularly valuable as we mature and grow our cardiovascular franchise.
Biographies of the DirectorsWhose Terms Expire at the 2017Annual Meeting of Stockholders.
Spencer R. Berthelsen,
M.D., age 62, has served as a Director of Isis sinceMay 2002. Since 1980, he has
practiced Internal Medicine with the Kelsey Seybold Clinic, a 370 physician medical group based in the Texas
Medical Center in Houston. Dr. Berthelsen has served in various senior leadership positions at Kelsey Seybold,
including Chairman of the Department of Internal Medicine, Medical Director andManaging Director. He has
been Chairman of their Board of Directors since October 2001. He has served as a Clinical Professor of
Medicine at Baylor College of Medicine and the University of Texas Health Science Center of Houston.
Dr. Berthelsen served on the board of the Texas Academy of Internal Medicine in the past and the Caremark
National Pharmacy and Therapeutics Committee from 1999 through 2005.
The Board believes Dr. Berthelsen is uniquely suited to serve on the Board because of his current position
managing a large multi-specialty group practice and 32 years of experience as a practicing physician.
B. Lynne Parshall,
age 60, has served as a Director of Isis since September 2000. She has been our Chief
Operating Officer since December 2007 and previously served as our Chief Financial Officer from June 1994
through December 31, 2012. She also served as our Corporate Secretary through 2014, and has served with the
Company in various executive roles since November 1991. Prior to joining Isis, Ms. Parshall practiced law at
Cooley LLP, outside counsel to Isis, where she was a partner from 1986 to 1991. Ms. Parshall is a member of
theAmerican, California and San Diego bar associations. Ms. Parshall serves on the board of directors of
Regulus Therapeutics, Inc. and Cytokinetcs Inc., two biopharmaceutical companies. Within the last five years,
Ms. Parshall formerly served as a Director of CardioDynamics International Corporation and Corautus Genetics
Inc., both biopharmaceutical companies.
The Board believes Ms. Parshall is uniquely suited to serve on the Board primarily because, as the Chief
Operating Officer and an executive of the Company for over 20 years, she has valuable Company-specific
experience and expertise. In addition, Ms. Parshall has over 25 years of experience structuring and negotiating
strategic licensing and financing transactions in the life sciences field.
JosephH. Wender,
age 70, has served as a Director of Isis since January 1994. Mr. Wender began with
Goldman, Sachs &Co. in 1971 and became a General Partner of that firm in 1982, where he headed the
Financial Institutions Group for over a decade. Since January 2008, he has been a Senior Consultant to Goldman
Sachs &Co. He is also an Independent Trustee of the Schwab Family of Funds and Director of Grandpoint
Capital, a bank holding company. Mr. Wender also is a managing partner and owns, with his wife, Colgin
Cellars. As of March 2014, Mr. Wender is a director of Outfront Media, lessors of advertising space on
out-of-home advertising structures.
The Board believes Mr. Wender is uniquely suited to serve on the Board primarily because, with over
40 years of experience as an investment banker with Goldman, Sachs &Co., he provides Isis important advice
regarding our financial reporting, corporate finance matters, strategic transactions, and compensation matters.
Mr. Wender is also highly qualified to serve on theAudit Committee.
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