BMS275291: selective matrix metalloproteinase inhibitor in cancer chemotherapy
Mechanism: angiogenesis inhibition
- potent inhibitor of MMPs 2 & 9; low activity vs. sheddases
- no tendonitis at high doses
Ph III in non-small cell lung cancer
- Taxol®/Paraplatin® ± BMS275291 (interim analysis 02)
Phase II in other cancers
Celltech-BMS agreement
- substantial milestones
- royalties on worldwide sales