ACT - Broader Spectrum than Current Targeted Therapy

Ras

PI3-

kinase

Apoptosis

S

G2

M

G1

HERCEPTIN

Bcr-Abl

Cytokines

Wnt

IRESSA

GLEEVEC

AVASTIN

ERBITUX

Checkpoint Activation

Antiproliferative

Cyclin/CDK/kinase inhibition

X

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