p53 Program
Definition: p53 a major controller of G1/S checkpoints; “PUMA” (“p53 upregulated modulator of apoptosis”) mediates p53-induced apoptosis (Vogelstein et al., 2001)
Objective: Bypass p53 defect in cancer cells with small molecules that directly stimulate PUMA, reactivating the p53 checkpoint apoptosis pathway
Status: Cyclis has licensed exclusive worldwide rights to PUMA; small molecule screening underway