Safe Harbor

9/30/2004


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Table of Contents

PPT Slide

Safe Harbor

ArQule Profile

ArQule Product Portfolio

Extract from Wyeth R&D presentation June 2004

The ArQule Advantage

Oncology Opportunity

The Goal of Activated Checkpoint TherapySM (ACTSM ):

Mechanism of Action

PPT Slide

ACTSM - More Selective than Chemotherapy

ARQ 501 in combination with Taxol – Ovarian model

PPT Slide

ARQ 501: Safety Margin in animal models

ArQule’s Lead Anti-Cancer Compound ARQ 501

Clinical Development:ARQ 501 Phase 1 Trial

Centers of Excellence/Investigators

Phase 1 study update

Pharmacokinetics

Tumor response

Adverse events

Phase Ib/II plans

Research portfolio update

PPT Slide

Roche Partnership

ArQule Financials

Milestones 2004

ArQule Profile

Author: James Hu