Pursue Multiple Applications/Territories

SURGERY

TRAUMA

South Africa

U.S. (Orthopedic)

Europe (Orthopedic)

Far East

ISCHEMIA

U.S.

Phase I

Phase II

Phase III

File for Approval

RegulatoryApproval

Product Sales

Tentative 2003

2002

Strategy 3:

U.S.

Europe

Preclinical

CANCER

U.S.

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Now let me turn to development program.