Design Rationale: Referencing Comparable Studies

• Lovenox and Arixtra rates range from 35-56%

• Non-evaluable patient rates higher for shorter trials

• Oral dosing in perioperative period is biggest hurdle

  • In a study specifically looking at the incidence

Oral Heparin

*N Engl J Med, Vol. 344, No. 9, March 1, 2001; 619-625

of nausea and vomiting in THR patients

using morphine analgesia, the incidence of nausea was 76-88% and vomiting was 60-76%.**

**Anesth Analg 1996; 83 (5): 1055-9

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