PPT Slide
Oral Heparin: Competition
- Arixtra [Pentasaccharide] (Organon/Sanofi-Synthelabo)
- Injectable, Black Box warning on Label
- Major Bleeding 42% higher than LMWH
- Bleeding increases with age thus label to include warning for pts > than 65 yrs
- “Differences in efficacy and safety between Arixtra and enoxaparin may be influenced by factors such as timing of first dose after surgery.”
- Melagatran [Direct Thrombin Inhibitor] (Astra Zeneca)
- Long term safety an issue (e.g. elevated LFT’s , concern over destabilzation of atherosclerotic plaques)
- LMW heparins (Aventis, et. al)
- Injectable, black box warning, various approved doses depending on market indication and patients’ weight
Disadvantages of Marketed/Pending Products