Nuvelo is committed to building a valuable business through the discovery, development and commercialization of life improving therapeutics for human disease.

11/11/2003

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Nuvelo is committed to building a valuable business through the discovery, development and commercialization of life improving therapeutics for human disease.

Advancing Compounds Through the Clinic:Alfimeprase

Nuvelo & Amgen 50/50 Partnership

Alfimeprase Development is Moving Rapidly

Phase 1 Trial Reveals Anecdotal Signs of Efficacy

Important Lead Indication: Acute Peripheral Arterial Occlusion

Second Indication: Catheter Occlusion

>$500MM U.S. Market

Value Driving Drug Discovery Engine

Maximizing Potential Through Strategic Business Development Activity

Selected Key Financials

Near-Term Milestones

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