Important Lead Indication: Acute Peripheral Arterial Occlusion
Acute obstruction of blood flow to the leg by a clot
,000 cases reported annually in the U.S.
Limited treatment options: bypass surgery, angioplasty or off-label use of thrombolytics (e.g. Abbokinase®, Activase®)
Currently no approved, widely used products on
the market
- Received orphan drug status
Major morbidity: tissue death, gangrene,