15. Quarterly Financial Information (Unaudited)

     The following is a summary of quarterly financial results for the fiscal years 2001 and 2000:

                                     
4Q ’01 3Q ’01 2Q ’01 1Q ’01
In thousands, except per share data
Statements of Operations Data:
Total revenues   $ 970     $ 946     $ 838     $ 735  
Gross profit (loss)     (108 )     43       (76 )     (35 )
Operating expenses:                                
  Research & development     7,123       10,297       9,002       8,187  
  Sales and marketing     737       784       664       622  
  General & administration     2,001       1,538       8,753       3,073  
    Total operating expenses     9,861       12,619       18,419       11,882  
Loss from operations     (9,969 )     (12,576 )     (18,495 )     (11,917 )
Other income, net     578       654       990       1,316  
Net loss   $ (9,391 )   $ (11,922 )   $ (17,505 )   $ (10,601 )
Per share data:                                
  Basic net loss per common share   $ (0.37 )   $ (0.47 )   $ (0.70 )   $ (0.42 )
  Weighted-average shares used in computing basic
    net loss per common share
    25,208       25,134       24,958       24,960  


                                     
4Q ’00 3Q ’00 2Q ’00 1Q ’00
In thousands, except per share data
Statements of Operations Data:                                
Total revenues   $ 920     $ 836     $ 710     $ 598  
Gross profit (loss)     (352 )     (379 )     (392 )     (591 )
Operating expenses:                                
  Research & development     3,747       6,229       8,143       8,259  
  Sales and marketing     698       617       569       579  
  General & administration     3,501       1,529       1,736       3,112  
    Total operating expenses     7,946       8,375       10,448       11,950  
Loss from operations     (8,298 )     (8,754 )     (10,840 )     (12,541 )
Other income, net     1,502       1,563       933       358  
Net loss   $ (6,796 )   $ (7,191 )   $ (9,907 )   $ (12,183 )
Per share data:
  Basic net loss per common share   $ (0.27 )   $ (0.29 )   $ (0.42 )   $ (0.55 )
  Weighted-average shares used in computing basic
    net loss per common share
    24,937       24,933       23,580       22,282  

     In the third quarter of fiscal 2001, research and development expenses include a one-time expense of $1,604,000, of which $1,511,000 is non-cash, for intellectual property and pre-clinical studies related to the acquisition of Reperfusion Systems, Inc., an inactive company 26% owned by Biopure.

     General and administrative expenses include non-cash compensation expense for stock options and warrants granted to certain consultants and directors. This non-cash compensation must be accounted for at fair value, per SFAS 123 and EITF 96-18, and be amortized over the vesting period and revalued each quarter based on the closing stock price. The quarterly expenses/(credits) to operations for fiscal 2001 were ($80,000), ($793,000), $6,370,000 and $1,347,000 for the fourth, third, second and first quarters, respectively. The quarterly expenses/(credits) to operations for fiscal 2000 were $1,895,000, ($34,000), $131,000 and $1,688,000 for the fourth, third, second and first quarters, respectively.