Neurotropism of Lister vs. LC16m8

Lister

LC16m8

log10 TCID50/ml

1.0

2.0

3.0

1.0

2.0

3.0

log10 PFU50/ml

Virus recovery from the

blood and brain of mice

inoculated intra-peritoneally

(Hashizume et al 1975)

LC16m8 shows no evidence of neurotoxicity in children

% w/transient EEG abnormalities

Lister: 26.3

LC16m8: 0

Source: Yamaguchi, Clinic and Virus 1975;3(3)269-79

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