Beta-cell Defect

120

Time (min)

Plasma Insulin (µU/mL)

Ward W et al. Diabetes Care 1984; 7:491–502

120

90

60

30

0

-30

IV glucose

80

40

0

Loss of First Phase Insulin Secretion

Non-Diabetics

Type 2 Diabetes

• Earliest evidence of failing beta cell

• Defect worsens over time

• Not corrected by current therapies

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