Company Overview

12/16/2004


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Table of Contents

PPT Slide

Safe Harbor Statement

Company Overview

Our Vision

Charles River Laboratories

Essential to the Process

Inveresk Merger

Inveresk Merger

Branding

Leading Capabilities Across the Drug Discovery and Development Pipeline

Uniquely Diverse Portfolio

Diversified Client Base

The New CRL – Reporting Segments

Global Footprint

Research Models and Services

Research Models and Services

Research Model Services

Pre-Clinical Services

Clinical Services

Clinical Services

Management Changes

Pre-Clinical Management Changes

Clinical Management Changes

Integration Update

Integration Update

2005 Synergies

2006 Synergies

Significant Market Opportunity

Forward Momentum

Reaffirming Q4 Guidance

Reaffirming 2004 Guidance

2004 Highlights

2005 Guidance

Future Direction

CRL: A Smart Investment

Financial Review

Net Sales

Sales Growth Drivers

Operating Margin

Margin Improvement Drivers

GAAP EPS

Non-GAAP EPS

EPS Improvement Drivers

Free Cash Flow

Cash Flow Improvements

New Debt Structure

Debt Structure

2004 4Q and Full-Year Guidance

2004 4Q Drivers

2005 Sales Guidance

2005 Amortization

2005 Guidance

2005 Cash Flow Guidance

SOX-404 Compliance

Summary

Pre-Clinical Services

Pre-Clinical Services

Management Structure

Pre-Clinical Locations

Creating Competitive Advantage

Pre-Clinical Vision

Integration

Sales and Marketing

Best Practices

Capacity Plans

Dedicated Capacity

Highly Complementary Service Offering

Leader in Specialty Toxicology

Unequaled Expertise in Repro Tox

Unequaled Expertise in Biologics

General Toxicology

Leadership in Pathology Services

Full-Service Preclinical Services

Strategic Growth Opportunities

Clinical Services

Clinical Services

Phase I

Phase I

European Clinical Trial Directive

Phase II-IV

Medical Data Services

Regulatory Affairs

Clinical Locations

Clinical Services Strategy

Core Market Growing at ~12.5%

Therapeutic Expertise

Therapeutic Area Focus

CRO Key Success Factors

Creating Competitive Advantage

Delivering Competitive Advantage

Delivering Competitive Advantage

Delivering Competitive Advantage

Growing Clinical Opportunity

Research Models and Services

RMS Overview

Research Models & Services (RMS)

Worldwide Market Opportunity

Research Models Worldwide Capacity

PPT Slide

Strategic Imperatives

Worldwide Strategies for Growth

Worldwide Strategies for Growth

Disease Models

Interrelated Disease Complications

Future Disease Models

Surgical Services

Capacity Additions

Hollister Expansion

Transgenic & Laboratory Services

Laboratory Services

Worldwide Strategies for Growth

In Vitro Detection Systems

FDA Mandated Assay

PTS Product Update

Vaccine Support Sales

Vaccine Support Strengths

Future Direction

Author: kblomquist