Oral Insulin: Overnight Study Summary
In patients with type 2 diabetes:
Bedtime dosing with oral insulin suppresses overnight-fasting insulin secretion
Bedtime dosing with oral insulin may improve fasting hepatic insulin sensitivity, evidenced by unchanged fasting glycemia with reduced fasting insulinemia
The physiologic actions of oral insulin are exerted far longer (ɴ hrs) than predicted by its rapid systemic pharmacokinetics (Cmax @ 25 min)
Oral insulin at bedtime may spare ß-cell function
As a first line therapy, oral insulin has the potential to slow the progression of Type 2 diabetes by improving the longevity of beta cells