Years Ended December 31,
(in thousands, except per share data)	1994			1995			1996		1997			1998
Statement of Operations Data:
Total Revenues	$	-		$	586		$	28,020	$	23,828		$	12,483
Costs and Expenses:
Cost of sales		-			-			-		2,585			2,036
Research and development		2,869			9,688			18,761		30,293			37,722
General and administrative		2,369			4,367			6,736		9,076			10,546
Compensation — warrants		991			-			-		-			-
Total costs and expenses		6,229			14,055			25,497		41,954			50,304
Operating income (loss)		(6,229	)		(13,469	)		2,523		(18,126	)		(37,821	)
Other income, net		332			832			2,550		6,689			8,123
Net income (loss)	$	(5,897	)	$	(12,637	)	$	5,073	$	(11,437	)	$	(29,698	)
Basic earnings (loss) per common share (1)	$	(1.45	)	$	(1.72	)	$	0.39	$	(0.65	)	$	(1.52	)
Average common shares outstanding (1)		4,067			7,354			13,001		17,570			19,479
Diluted earnings (loss) per common share (1)	$	(1.45	)	$	(1.72	)	$	0.35	$	(0.65	)	$	(1.52	)
Average common and dilutive
equivalent shares outstanding (1)		4,067			7,354			14,634		17,570			19,479
	December 31,
(in thousands)	1994			1995			1996		1997			1998
Balance Sheet Data:
Cash, cash equivalents and investments (2)	$	11,834		$	19,454		$	77,439	$	160,219		$	128,261
Total assets (2)		14,562			26,048			93,659		180,081			151,028
Long-term debt		1,431			4,696			10,905		10,926			8,766
Total stockholders' equity		11,421			17,773			75,877		158,294			130,379
(1) For information concerning the calculation of earnings (loss) per share, see Note 16, "Earnings (loss) per share," to the footnotes to our Consolidated Financial Statements on page 41.
(2) Includes restricted investments of $1.2 million, $3.6 million, $10.1 million, $12.1 million, and $16.5 million at December 31, 1994, 1995, 1996, 1997 and 1998, respectively. See Notes 7 and 8, "Indebtedness" and "Leases," to the footnotes to our Consolidated Financial Statements.