Agenda

3/4/2002


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Table of Contents

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Ligand’s Core Strategy: Build Two Diversified Profit Centers

Our Strategy is Paying Off

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Our Pipeline is Among Biotech’s Best

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We Are Approaching Operating Break-Even on a Quarterly Basis

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Morphelan™ Will Contribute Significant Value to our LSPP Portfolio

Morphelan Product Profile

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Morphelan Versus OxyContin

SR Opioid Market is Growing Rapidly

2001 SR Opioid $ Market Share ($mm)

Oncology Pain Market Assessment

Ligand Sales Force Strategy for Morphelan

LSPP Development Priorities

ONTAK Has Significant Potential in Other Cancers, Autoimmune Diseases

ONTAK Growth in Expanded Use

Targretin Gel Has Exciting Potential in Dermatologic Disorders

Targretin Capsules Have Enormous Potential in Lung Cancer

Market Opportunity Non-Small Cell Lung Cancer (NSCLC)

Benefit of Targretin® Capsules in NSCLC

NSCLC Phase III Registration Program for First-Line Therapy

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LCPP Products May be Breakthroughs in Several Fields

LCPP Pipeline is Poised to Deliver Major Royalty, Milestone Income

Market Opportunity Osteoporosis / Osteopenia

Market Opportunity HRT (Female)

Ligand Partners’ Second Generation SERMs

Benefits of Lasofoxifene

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TSE-424 vs. Raloxifene Activity on Bone Markers

TSE-424 / PREMARIN® Combination: New Concept in HRT

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Continuum of Excellence in Women’s Health Products

Therapeutic Advantages of Second Generation SERMs

Market Opportunity Diabetes and Dyslipidemias

Ligand’s Partnered Drugs for Diabetes / Dyslipidemias

Ligand / TAP Pharmaceutical Products Collaborative Research Program

Ligand / TAP Pharmaceutical Products Collaborative Research Program

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Historical Financial Results

Ligand Pharmaceuticals Incorporated Income Statement and Balance Sheet

What’s Next for Ligand?

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Strategic Priorities 2002-2004

Upcoming Value Driving Events

Upcoming Value Driving Events

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Author: cab