Historical Financial Results

Revenues:

Product $ .4 $11.3 $22.9 $ 16.2 $ 30.0

Collaborative and other 17.3 29.6 25.2 18.1 23.7

Total Revenues 17.7 40.9 48.1 34.3 53.7

Total Operating Expenses (1) 86.8 86.7 85.4 64.4 64.7

Loss from Operations (1) (69.6) (56.3) (45.9) (36.5) (20.6)

1998

1999

9/30/00

9/30/01

9 Months Ended

($ in thousands)

(1) Does not include one-time charges

FY Ended 12/31

2000