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2005 Annual Report

Introduction
Thrombus Basics
Proprietary Technology
Market Presence
Business Model
Plans for Growth
Expanding Markets
Shareholder Letter
Glossary
Company Info

Three proprietary components,
#1 thrombectomy choice

Possis was the first to enter the mechanical thrombectomy market with our introduction of the AngioJet system in 1997. Today it is still the physician’s top choice for thrombectomy. The AngioJet system encompasses three basic components: The drive unit, pump set, and catheters. We are continuously advancing our product line.

The drive unit monitors safety and assures balanced flow and volume of the saline solution delivered to the single-use pump set. The pump set provides effective and sterile fluid delivery into the catheter. Possis catheters are thin, flexible tubes inserted into blood vessels with a guidewire. They are designed and approved for a variety of indications.

Our proprietary portfolio creates a substantial entry barrier for competitors. It includes:

  • 25 U.S. patents
  • 6 patents outside U.S.
  • 16 U.S. patent applications
  • 16 patent applications outside U.S.

    Strategic extensions of our product portfolio

    Our highly-trained staff of 80 sales people and clinical sales specialists stay on top of current practice methodologies through close collaboration with interventional cardiologists, radiologists, and vascular surgeons. They also work closely with Possis research and development experts, conveying their first-hand knowledge of real-world clinical needs. The result is our growing portfolio of new and well-accepted products.

    The new AngioJet Spiroflex™ catheter is an improved version of our best-selling coronary catheter, ideal for difficult anatomy. Initial physician feedback has exceeded our expectations. Our powerful new DVX™ catheter, initially approved for peripheral arterial applications, holds enormous application potential in the venous thrombosis market. With five times the evacuation power of earlier models, it can tackle older, tougher thrombus in large peripheral vessels. The Power Pulse™ delivery system, approved for use in 2004, is rapidly gaining ground as a more effective and potentially safer treatment for difficult peripheral thrombus. The most exciting addition to our growing portfolio? The new AngioJet Ultra™ System. With its integrated disposable components and totally re- engineered drive unit, the Ultra System will significantly simplify the set-up and operation of AngioJet Thrombectomy for busy hospital staff.

     

  • “Until recently, there were no consistently effective interventional therapies for removing the larger, tougher clots found in peripheral vessels. The AngioJet Thrombectomy System has become a valuable tool in the treatment of peripheral vascular disease. And with the option of Power Pulse Delivery, I can now resolve many of my patients’ peripheral clots – often with just one visit to the cath lab. AngioJet’s successful arterial applications suggest it may be just as effective in the treatment of deep vein thrombosis, which at this time has no aggressive treatment options. Future research will determine the safety of this device in DVT therapy.”

    Anthony C. Venbrux, MD
    Interventional Radiologist
    The George Washington University Medical Center