Lessons from Landmark Diabetes Studies:Intervention Works

• Continuous relationship between glucose concentrations (HbA1c) and complication risk

• Lowering HbA1c reduces risk of complications

• No threshold effect, the lower the better

Diabetes 1996,45:1289-1298

Lancet 1998;352:837-853

DCCT (Type 1)

Microvascular complications

16

12

8

4

0

5

6

7

8

9

10

11

12

HbA1c (%)

Rate/100 Patient Years

UKPDS (Type 2)

HbA1c (%)

Incidence/100 Patient Years

8

6

4

2

0

5

6

7

8

9

10

11

Microvascular complications

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