Year Ended October 31,
2001 2000 1999
In thousands
Operating activities:
Net loss   $ (49,419 )   $ (36,078 )   $ (35,530 )
Adjustments to reconcile net loss to net cash used in operating activities:
  Depreciation and amortization     3,643       4,107       3,931  
  Disposition of obsolete fixed assets     —       331       —  
  Equity compensation     6,844       3,681       75  
  Deferred compensation     7       (3 )     (122 )
  Accrued interest on stockholders’ notes receivable     (90 )     (126 )     (172 )
  Stock issued for interest in Reperfusion     1,511       —       —  
  Equity in affiliate’s operations     34       35       30  
  Changes in assets and liabilities:
    Accounts receivable     (246 )     (157 )     25  
    Inventories     (1,939 )     456       (110 )
    Other current assets     (391 )     108       302  
    Accounts payable     (416 )     1,023       (782 )
    Accrued expenses     (771 )     (436 )     1,394  
      Net cash used in operating activities     (41,233 )     (27,059 )     (30,959 )
Investing activities:                        
Purchases of property and equipment     (3,265 )     (2,052 )     (1,772 )
Escrow for new facility     (10,000 )     —       —  
Other assets     (98 )     165       1,531  
      Net cash used in investing activities     (13,363 )     (1,887 )     (241 )
Financing activities:
Net proceeds from sale of common stock     —       83,751       37,702  
Expenses related to equity line     (675 )     —       —  
Net proceeds from sale of preferred stock     —       —       30,125  
Payment of long-term debt     —       —       (6,000 )
Repurchase of common stock     —       —       (6,000 )
Proceeds from exercise of stock options, warrants and restricted stock     2,064       2,689       88  
Payment of notes receivable from shareholders     468       556       —  
      Net cash provided by financing activities     1,857       86,996       55,915  
     
     
     
 
Increase (decrease) in cash and cash equivalents     (52,739 )     58,050       24,715  
Cash and cash equivalents at beginning of the year     88,828       30,778       6,063  
Cash and cash equivalents at end of the year   $ 36,089     $ 88,828     $ 30,778  
Interest paid   $ —     $ —     $ 435  
Non-cash investing transactions:
Land and license rights acquired upon exercise of stock option   $ 1,005     $ —     $ —  
New facility construction financed through capital lease (classified
     as long-term debt)
  $ 5,205     $ —     $ —  

See accompanying notes.