>$500MM U.S. Market
Peripheral Arterial Occlusion
- 1998 U.S. sales of Abbokinase® were ~$280MM (off-label use for less than one year)
- No widely used products currently on the market
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Catheter Occlusion
- U.S. central catheter occlusion cases of > 1million
- Current treatment: surgery or Cathflo®Activase®
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Deep Vein Thrombosis
- Affects over 2 million Americans per year; ~600,000 hospitalizations
- Third most common cardiovascular disease (behind ACS and stroke)
- May be treated with catheter directed lysis (infusions up to 3 days)