Year Ended October 31,
2001 2000 1999
In thousands
Operating activities:
Net loss   $ (49,419 )   $ (36,078 )   $ (35,530 )
Adjustments to reconcile net loss to net cash used in operating activities:
  Depreciation and amortization     3,643       4,107       3,931  
  Disposition of obsolete fixed assets           331        
  Equity compensation     6,844       3,681       75  
  Deferred compensation     7       (3 )     (122 )
  Accrued interest on stockholders’ notes receivable     (90 )     (126 )     (172 )
  Stock issued for interest in Reperfusion     1,511              
  Equity in affiliate’s operations     34       35       30  
  Changes in assets and liabilities:
    Accounts receivable     (246 )     (157 )     25  
    Inventories     (1,939 )     456       (110 )
    Other current assets     (391 )     108       302  
    Accounts payable     (416 )     1,023       (782 )
    Accrued expenses     (771 )     (436 )     1,394  
      Net cash used in operating activities     (41,233 )     (27,059 )     (30,959 )
Investing activities:                        
Purchases of property and equipment     (3,265 )     (2,052 )     (1,772 )
Escrow for new facility     (10,000 )            
Other assets     (98 )     165       1,531  
      Net cash used in investing activities     (13,363 )     (1,887 )     (241 )
Financing activities:
Net proceeds from sale of common stock           83,751       37,702  
Expenses related to equity line     (675 )            
Net proceeds from sale of preferred stock                 30,125  
Payment of long-term debt                 (6,000 )
Repurchase of common stock                 (6,000 )
Proceeds from exercise of stock options, warrants and restricted stock     2,064       2,689       88  
Payment of notes receivable from shareholders     468       556        
      Net cash provided by financing activities     1,857       86,996       55,915  
     
     
     
 
Increase (decrease) in cash and cash equivalents     (52,739 )     58,050       24,715  
Cash and cash equivalents at beginning of the year     88,828       30,778       6,063  
Cash and cash equivalents at end of the year   $ 36,089     $ 88,828     $ 30,778  
Interest paid   $     $     $ 435  
Non-cash investing transactions:
Land and license rights acquired upon exercise of stock option   $ 1,005     $     $  
New facility construction financed through capital lease (classified
     as long-term debt)
  $ 5,205     $     $  

See accompanying notes.