PPT Slide

Inadvertent inoculation 25.4 27.1

Generalized vaccinia 23.4 17.7

Erythema multiforme

Total serious (but not life-threatening reactions) 48.8

Source: CDC.Smallpox adverse event rates, 1968. Atlanta, GA:US Department of Health and Human Services, CDC, 2002

Smallpox Vaccine Adverse Event Rates – U.S., 1968

National survey

All first time

ɭ yr. old

Serious (but not life-threatening reactions)

1.1 0.6

Life-threatening reactions

Postvaccinal encephalitis/encephalomyelitis 2.9 2.4

Progressive vaccinia (vaccinia necrosum) 0.9 1.0

Eczema vaccinatum 10.4 10.6

Total number of life-threatening reactions 14.2

Deaths

* Not available.

† None reported.

NA*

Number per million vaccinees

“The least safe vaccine ever used on a wide scale” (IOM, January 2003)