Smallpox

• Problem: Conventional smallpox vaccines are inappropriate for preemptive use

• Vaccine risk ? reward of preemptive protection
• Civilian immunization program suspended
  • Escalating concerns over known risks
  • Unanticipated deaths from myocarditis

• Government’s proposed solution:

• A safer, attenuated smallpox vaccine is needed
• Project BioShield: purchase an attenuated smallpox vaccine

Solution:

Immunize prior to a smallpox outbreak

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