2005 Annual Report: OSI Pharmaceuticals

Board of Directors

Robert A. Ingram
Chairman of the Board
Vice Chairman, Pharmaceuticals
GlaxoSmithKline

Colin Goddard, Ph.D.
Chief Executive Officer

G. Morgan Browne
Former Chief Financial Officer
and Administrative Director
Cold Spring Harbor Laboratory

Daryl K. Granner, M.D.
Director, Vanderbilt Diabetes
Center; Professor, Molecular
Physiology and Biophysics,
Vanderbilt University

Walter M. Lovenberg, Ph.D.
Former Executive Vice President
Marion Merrell Dow Inc.

Viren Mehta
Mehta Partners LLC

Herbert Michael Pinedo, M.D., Ph.D.
Professor of Medical Oncology
Director of the VUMC Cancer
Center– Amsterdam

Sir Mark Richmond
Formerly Head of Research and
Special Assignments,
Glaxo Research & Development

Katharine B. Stevenson
Treasurer
Nortel Networks Inc.

John P. White, Esq.
Partner
Cooper & Dunham LLP

Executive Management Committee

Colin Goddard, Ph.D.
Chief Executive Officer

Michael G. Atieh
Executive Vice President
and Chief Financial Officer

Paul G. Chaney
Chief Operating Officer,
OSI Eyetech

Neil Gibson, Ph.D.
Vice President and
Chief Scientific Officer

David R. Guyer, M.D.
Executive Vice President and
Chief Executive Officer,
OSI Eyetech

Gabriel Leung
Executive Vice President and
President, OSI Oncology

Anker Lundemose, M.D., Ph.D.
Executive Vice President and
President, OSI Prosidion

Robert L. Simon
Executive Vice President, Core
Development and Manufacturing

Barbara A. Wood, Esq.
Vice President, General Counsel
and Secretary

Corporate Headquarters

OSI Pharmaceuticals, Inc.
41 Pinelawn Road
Melville, NY 11747

Other Company Locations

Oncology Research – New York
1 Bioscience Park Drive
Farmingdale, NY 11735

Oncology Development –
Colorado
2860 Wilderness Place
Boulder, CO 80301

Prosidion – Diabetes Research &
Development
Watlington Road
Oxford, UK, OX4 6LT

Eyetech – New York
3 Times Square
12th Floor
New York, NY 10036

Eyetech – CMC Cedar Knolls
140 Hanover Avenue
Cedar Knolls, NJ 07927

Transfer Agent
& Registrar
Bank of New York
101 Barclay Street
New York, NY 10286
(800) 524-4458
http://www.stockbny.com

Corporate Counsel
Saul Ewing LLP
Centre Square West
1500 Market Street
Philadelphia, PA 19102

General Counsel
Mintz, Levin
666 Third Avenue
New York, NY 10017

Patent Counsel
Cooper & Dunham LLP
1185 Avenue of The Americas
New York, NY 10036

Auditors
KPMG LLP
1305 Walt Whitman Road
Melville, NY 11747

Annual Meeting
The annual meeting of
shareholders will be held on
June 14, 2006 at 10:00 am at
OSI Pharmaceuticals, Inc.
(Corporate Headquarters)
41 Pinelawn Road
Melville, NY 11747

Annual Report on Form 10-K
The Company’s Annual Report
on Form 10-K filed with the
Securities and Exchange
Commission and other informa-
tion may be obtained without
charge by writing, phoning or
visiting our website:

OSI Pharmaceuticals, Inc.
41 Pinelawn Road
Melville, NY 11747
(631) 962-2000
www.osip.com

Stock Listing
Nasdaq: OSIP