81
SIGNATURES
Pursuant to the requirements of Section13or 15(d) of theSecurities ExchangeAct of 1934, theRegistrant has duly caused
this report onForm10-K tobe signedon its behalf by the undersigned, thereuntoduly authorizedon the 28thdayof February, 2014.
ISISPHARMACEUTICALS, INC.
By: /s/ STANLEYT. CROOKE
StanleyT. Crooke,M.D., Ph.D.
Chairmanof theBoard, President andChief Executive
Officer (Principal executive officer)
POWEROFATTORNEY
KNOWALLMENBYTHESEPRESENTS, that eachpersonwhose signature appears below constitutes and appoints
StanleyT. Crooke andElizabethL. Hougen, or any of them, his or her attorney-in-fact, eachwith the power of substitution, for himor
her in any and all capacities, to sign any amendments to thisReport, and to file the same, with exhibits thereto and other documents in
connection therewith, with the Securities andExchangeCommission, hereby ratifying and confirming all that eachof said attorneys-
in-fact, or his or her substitute or substitutes,maydoor cause tobe done byvirtue hereof.
Pursuant to the requirements of theSecuritiesExchangeAct of 1934, this report has been signedbelowby the following
persons onbehalf of theRegistrant and in the capacities andon the dates indicated.
Signatures
Title
Date
/s/ STANLEYT. CROOKE
Chairman of theBoard, President, andChief ExecutiveOfficer
February28, 2014
StanleyT. Crooke,M.D., Ph.D.
(Principal executive officer)
/s/ B. LYNNEPARSHALL
Director, ChiefOperatingOfficer andSecretary
February28, 2014
B. Lynne Parshall, J.D.
/s/ ELIZABETHL. HOUGEN
SeniorVice President, Finance andChief FinancialOfficer
February28, 2014
ElizabethL. Hougen
(Principal financial and accountingofficer)
/s/ SPENCERR. BERTHELSEN Director
February28, 2014
Spencer R. Berthelsen,M.D.
/s/ BREAUXCASTLEMAN
Director
February28, 2014
BreauxCastleman
/s/ JOSEPHKLEIN
Director
February28, 2014
JosephKlein, III.
/s/ JOSEPHLOSCALZO
Director
February28, 2014
JosephLoscalzo,M.D., Ph.D.
/s/ FREDERICKT.MUTO
Director
February28, 2014
FrederickT.Muto, Esq.
/s/ JOSEPHH.WENDER
Director
February28, 2014
JosephH.Wender
