85
10.50
Amendment #1 toCollaboration, License andDevelopment Agreement between theRegistrant andAstraZeneca
ABdatedAugust 13, 2013. Portions of this exhibit have beenomitted and separately filedwith theSECwith a
request for confidential treatment. (34)
10.51
Amendment Number Three to theAmended andRestatedLicense andCollaborationAgreement among the
Registrant, AlnylamPharmaceuticals, Inc. andRegulusTherapeutics Inc. datedAugust 2, 2013. Portions of this
exhibit have beenomitted and separately filedwith theSECwith a request for confidential treatment. (34)
14.1 Registrant’sCode of Ethics andBusinessConduct. (36)
21.1 List of Subsidiaries for theRegistrant.
23.1 Consent of Independent RegisteredPublicAccountingFirm.
24.1 Power ofAttorney. (28)
31.1
CertificationbyChief ExecutiveOfficer Pursuant to18U.S.C. Section1350 asAdoptedPursuant toSection302
of theSarbanes-OxleyAct of 2002.
31.2
CertificationbyChief FinancialOfficer Pursuant to18U.S.C. Section1350 asAdoptedPursuant toSection302of
the Sarbanes-OxleyAct of 2002.
32.1
CertificationPursuant to18U.S.C. Section1350 asAdoptedPursuant toSection906of theSarbanes-OxleyAct of
2002.
99.2 FormofConfidentialityAgreement. (8)
101
The following financial statements from the Isis Pharmaceuticals, Inc. Annual Report onForm10-K for the year
endedDecember 31, 2013, formatted inExtensiveBusinessReportingLanguage (XBRL): (i) consolidated balance
sheets, (ii) consolidated statements of operations, (iii) consolidated statements of stockholders’ equity,
(iv) consolidated statements of cash flows, and (v) notes to consolidated financial statements (detail tagged).
(1)
Filed as an exhibit to theRegistrant’sRegistrationStatement onFormS-1 (No. 33-39640) or amendments thereto and
incorporatedhereinby reference.
(2)
Filed as an exhibit toRegistrant’sQuarterlyReport onForm10-Q for the quarter endedMarch31, 2006.
(3)
Filed as an exhibit to theRegistrant’sQuarterlyReport onForm10-Q for the quarter endedSeptember 30, 2011 and
incorporatedhereinby reference.
(4)
Filed as an exhibit to theRegistrant’sQuarterlyReport onForm10-Q for the quarter endedMarch31, 2009 and
incorporatedhereinby reference.
(5)
Filed as an exhibit to theRegistrant’sQuarterlyReport onForm10-Q for the quarter endedMarch31, 2008 and
incorporatedhereinby reference.
(6)
Filed as an exhibit to theRegistrant’sAnnual Report onForm10-K for the year endedDecember 31, 1998 and incorporated
hereinby reference.
(7)
Filed as an exhibit to theRegistrant’sAnnual Report onForm10-K for the year endedDecember 31, 1999 and incorporated
hereinby reference.
(8)
Filed as an exhibit to theRegistrant’sRegistrationStatement onFormS-3 (No. 333-71911) or amendments thereto and
incorporatedhereinby reference.
(9)
Filed as an exhibit to theRegistrant’sQuarterlyReport onForm10-Q for the quarter ended June 30, 2008 and incorporated
hereinby reference.
