83
10.13
Amended andRestatedLicenseAgreement dated July2, 2008between theRegistrant andOncoGenex
Technologies Inc. Portions of this exhibit have beenomitted and separately filedwith theSECwith a request for
confidential treatment. (17)
10.14
LeaseAgreement between theRegistrant andBMR-GazelleCourt LLCdatedMarch30, 2010. Portions of this
exhibit have beenomitted and separately filedwith theSECwith a request for confidential treatment. (25)
10.15
SecondAmendment toLeaseAgreement datedMay15, 2011between theRegistrant andBMR-GazelleCourt
LLC, withFirst Amendment toLeaseAgreement included. (10)
10.16
Registrant’sAmended andRestated Isis Pharmaceuticals, Inc. 10b5-1TradingPlandatedSeptember 12, 2013.
(34)
10.17* Registrant’sAmended andRestated 2002Non-EmployeeDirectors’ StockOptionPlan, as amended. (27)
10.18* Registrant’s Formof 2002Non-EmployeeDirectors’ StockOptionAgreement. (21)
10.19*
Formof RestrictedStockUnit Agreement for RestrictedStockUnits granted under the Isis Pharmaceuticals, Inc.
2002Non-EmployeeDirectors’ StockOptionPlan. (32)
10.20*
Amended andRestatedSeveranceAgreement datedDecember 3, 2008between theRegistrant andStanleyT.
Crooke. (16)
10.21*
Amended andRestatedSeveranceAgreement datedDecember 3, 2008between theRegistrant andB. Lynne
Parshall. (16)
10.22
Amended andRestatedStrategicCollaboration andLicenseAgreement datedApril 28, 2009between the
Registrant andAlnylamPharmaceuticals, Inc. Portions of this exhibit have beenomitted and separately filedwith
theSECwith a request for confidential treatment. (20)
10.23* Isis Pharmaceuticals, Inc. 2011Equity Incentive Plan (19)
10.24 LoanAgreement datedOctober 15, 2008between theRegistrant andRBSAsset Finance, Inc. (23)
10.25* FormofOptionAgreement forOptions grantedunder the 2011Equity IncentivePlan. (29)
10.26*
Formof RestrictedStockUnit Agreement forRestrictedStockUnits granted under the 2011Equity IncentivePlan.
(29)
10.27
SecondAmendment toLeaseAgreement between theRegistrant andBMR-2282FaradayAvenueLLCdated
March30, 2010. Portions of this exhibit have beenomitted and separately filedwith theSECwith a request for
confidential treatment. (25)
10.28* FormofOptionAgreement forOptionsGranted afterMarch8, 2005under the 1989StockOptionPlan. (11)
10.29*
FormofOptionAgreement forOptionsGranted afterMarch8, 2005under the 2000Broad-BasedEquity Incentive
Plan. (11)
10.30*
FormofOptionAgreement forOptionsGranted afterMarch8, 2005under the 2002Non-EmployeeDirector’s
StockOptionPlan. (11)
10.31
Research, Development andLicenseAgreement between theRegistrant andGlaxoGroupLimited datedMarch30,
2010. Portions of this exhibit have beenomitted and separately filedwith the SECwith a request for confidential
treatment. (25)
10.32
FirstAmendment toLoanAgreement between theRegistrant andRBSAsset Finance, Inc. datedSeptember 30,
2009. (24)
10.33 LeaseAgreement datedSeptember 6, 2005between theRegistrant andBMR-2282FaradayAvenueLLC. (18)
