Isis Pharmaceuticals, Inc. Form 10K - page 120

Item12. Security Ownership of Certain Beneficial Owners andManagement and Related Stockholder
Matters
Security Ownership of Certain Beneficial Owners andManagement
This table outlines the ownership of our common stock as of February 18, 2015 by:
each Director;
each executive officer named in the Summary Compensation Table under ‘‘Executive
Compensation--Compensation of Executive Officers’’;
all Directors and executive officers as a group; and
every entity that we know beneficially owns more than five percent of our common stock.
Beneficial Ownership
(1)
Beneficial Owner
Number of
Shares
Percent of
Total
(2)
FMR LLC
(3)
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
17,892,555 15.04
245 Summer Street
Boston, MA02210
BlackRock, Inc.
(4)
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
9,541,651
8.02
55 East 52
nd
Street
NewYork, NY10022
ClearBridge Investments, LLC
(5)
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
9,034,520
7.59
620 8
th
Avenue
NewYork, NY10018
The Vanguard Group
(6)
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
7,271,871
6.11
100 Vanguard Boulevard
Malvern, PA19355
BBBiotechAG
(7)
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
5,976,526
5.02
Vordergasse 3
CH-8200 Schaffhausen, Switzerland
Spencer R. Berthelsen
(8)
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
150,154
*
Breaux B. Castleman
(9)
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
9,845
*
Stanley T. Crooke
(10)
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1,198,094
1.0
Joseph Klein, III
(11)
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
14,321
*
Joseph Loscalzo
(12)
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
6,563
*
Frederick T. Muto
(13)
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
102,284
*
B. Lynne Parshall
(14)
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
73,060
*
Joseph H. Wender
(15)
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
111,906
*
Brett Monia
(16)
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
56,738
*
Richard S. Geary
(17)
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
49,501
*
Elizabeth L. Hougen
(18)
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
100,998
*
All Directors and executive officers as a group (fourteen persons)
(19)
. . . . . . . . . . . . . . . .
2,066,615
1.7
* Less than one percent
(1) We base this table upon information supplied by officers, Directors, principal stockholders and Form 3s, Form 4s, Form 5s, Schedules
13D and 13G filed with the SEC. Unless otherwise indicated in the footnotes to this table and subject to community property laws
where applicable, we believe that each of the stockholders named in this table has sole voting and investment power with respect to the
shares indicated as beneficially owned.
(2) Applicable percentages are based on 118,974,465 shares of common stock outstanding on February 18, 2015, adjusted as required by
rules promulgated by the SEC.
(3) Abigail P. Johnson is a Director, the Vice Chairman, the Chief Executive Officer and the President of FMR LLC. Members of the
family of Edward C. Johnson 3d, includingAbigail P. Johnson, are the predominant owners, directly or through trusts, of Series B
voting common shares of FMR LLC, representing 49%of the voting power of FMR LLC. The Johnson family group and all other
Series B shareholders have entered into a shareholders’ voting agreement under which all Series B voting common shares will be voted
in accordance with the majority vote of Series B voting common shares. Accordingly, through their ownership of voting common
shares and the execution of the shareholders’ voting agreement, members of the Johnson family may be deemed, under the Investment
CompanyAct of 1940, to form a controlling group with respect to FMR LLC.
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